Splenomegaly, glomerulonephritis, and IgG deposits were also much more significantly weaker in the Lyn−/−Irf5+/− strain and Lyn−/−Irf5−/− strain compared to strains Lyn−/−Ifnar1+/− and Lyn−/−Ifnar1−/− (Fig. 2b–f). This evidence concerns the gene LYN and glomerulonephritis.