Gene set enrichment analysis (GSEA) revealed that seven gene sets, including IFN-α response and OXPHOS gene sets, were significantly upregulated both in SLE patients and Lyn-deficient mice compared to healthy donors and wild-type (WT) mice, respectively (Fig. 2g and Supplementary Fig. 6c). The gene discussed is IFNA1; the disease is systemic lupus erythematosus.