We also detected the expression of p-AMPK (Fig. S8A, D), p-mTOR (Fig. S8B, D) and IRF-8 (Fig. S8C, D) in kidney in pristane-induced lupus mice and found that IRF-8 and mTOR were highly expressed in the kidney tissues of SLE mice, and INK128 and metformin could significantly inhibit the expression of IRF-8 and the phosphorylation of mTOR. Here, IRF8 is linked to systemic lupus erythematosus.