Its motifs were mostly mutated in digestive tract tumors (3,784 CTCF mutated motifs, P-value = 0.0097), esophagus cancers (1,154, P-value = 0.0097), liver-HCC (1,570, P-value = 0.0097), and skin melanomas (1,016, P-value = 0.0097, Fig 3B) (Katainen et al, 2015; Sabarinathan et al, 2016; Umer et al, 2016). Here, CTCF is linked to hepatocellular carcinoma.