85.8% of the mutations overlapped ENCODE DNaseI hypersensitive sites (DHSs) or TF binding sites (TFBSs) irrespective of cell type specificity (n = 105 cell lines) whereas only 3.7% of the mutations overlapped DHSs or TFBSs from cell lines matching the cancer types (Fig 1A). The gene discussed is TF; the disease is cancer.