TRIB2 and urinary bladder cancer: Interestingly, the intergenic region nearby TRIB2 was highly enriched for mutated elements (three elements with FDR < 0.0014), and its expression was significantly increased in the mutant bladder cancer samples compared to the samples that lacked mutations in the associated elements excluding samples that had copy number variants (CNVs) at the loci (Fig 5B, see the Materials and Methods section).