Tumor-infiltrating CD8+ cells showed a more active and cytotoxic phenotype in the combination group, as shown by the expression of the costimulatory molecules CD137 and GITR and the double-positive population PD-1+GrzB+ (p=0.001, p=0.002 and p=0.042, respectively, figure 6J). The gene discussed is TNFRSF18; the disease is neoplasm.