INS and Hypoglycemia: This therapeutic class requires sensitization and patients need to be informed of the risk of side-effects including: hypoglycemia in patients receiving insulin or sulfonylurea, genital infections and very rare cases of Fournier’s gangrene, volume depletion (hypotension, hypovolaemia and dehydration), rare cases of hyperglycemic or euglycemic ketoacidosis [11, 12] and the necessity to stop treatment prior to any surgery.