We identified 12 significant genes (at FDR 5%) in the brain and blood (AP000295.1, CCR3, CR936218.2, CRHR1, FYCO1, IFNAR2, IL10RB, IL10RB-AS1, LRRC37A4P, MAPT-AS1, OAS1, OAS3) that were associated with hospitalized COVID-19 patients, with respect to the general population. This evidence concerns the gene OAS3 and COVID-19.