IRF8 and COVID-19: We prioritized 4 out of 5 microglia PFC TFs (IRF8, ATF5, SPI1, TAL1) based on the upregulation in their activity in patients with COVID-19 (Z > 2.5, P < 0.05 and FDR within cell type < 0.05) (Fig. 4A; Additional file 9: Table S8).