Another study revealed that the same acupoints applied to acupuncture could alleviate airway hyperresponsiveness and mucus secretion as well as inhibiting NF-κB signaling which may be upstream of the M1-like cytokines in asthmatic mice, accompanied by reductions in the CD4+IL-17A+ cell numbers, eosinophils, and neutrophils, and increases in the CD4+Foxp3+ cell numbers in the bronchoalveolar lavage fluid. Here, CD4 is linked to airway hyperresponsiveness.