PPARG and obesity due to melanocortin 4 receptor deficiency: As a negative regulator of pro-inflammatory genes, PPARγ knockout in myeloid cells was found to reduce M2-like activation and induced susceptibility to obesity, insulin resistance, and glucose intolerance [74], while IL-4 and IL-13 regulated the expression of PPARγ in murine macrophages and human peripheral blood monocytes [75].