EGFR and lung carcinoma: Our previous work revealed that CMTM7 co-localizes with Rab5 on early endosomes and knockdown of CMTM7 increases tumorigenicity of lung cancer cells and EGFR-AKT signaling by reducing the activation of Rab5 [5], indicating that CMTM7 is involved in regulating intracellular membrane trafficking such as endocytosis and early endosome fusion.