It was shown that CRISPR Cas9 knockout and shRNA knockdown of FLI1 identified FECRs as a new noncanonical malignant driver in SCLC, as FECR1 (exons 4-2-3) and FECR2 (exons 5-2-3-4) were aberrantly upregulated in SCLC tissues, and positively correlated with lymph node metastasis. The gene discussed is FLI1; the disease is small cell lung carcinoma.