The mechanism underlying this process indicates that tumor-derived exosomal TRIM59 triggers macrophages to exhibit tumor-promoting activities by modulating abhydrolase domain containing 5 (ABHD5) proteasomal degradation, which activates the NLRP3 inflammasome signaling pathway and promotes lung cancer progression by IL-1β secretion [117]. The gene discussed is TRIM59; the disease is neoplasm.