To efficiently evade the host immune system, the tumor derives exosomes to modulate antitumor immune responses via the inhibition of T-cell activation and proliferation, induction of regulatory T-cells (Tregs) and myeloid-derived suppressor cells (MDSCs), and inhibition of natural killer (NK) and CD8 + T-cells function, thus facilitating tumor progression and metastasis [27, 28]. The gene discussed is CD8A; the disease is neoplasm.