Pretreatment of exosomes with Sanguinarine, a benzo[c]phenanthridine alkaloid obtained from the roots of Sanguinaria canadensis, effectively averted the effects of lung cancer-derived exosomes, including tumor cell proliferation, invasion, migration activities, and suppressed apoptosis via inhibition of macrophages and the NF-κB pathway [125]. This evidence concerns the gene NFKB1 and lung cancer.