EGFR and lung cancer: Lung cancer-derived exosomes are enriched in signal transduction molecules such as EGFR, GRB2, and SRC [65], and functional exosomal RNAs such as circSATB2 and miR-660-5p [66, 67], that actively modulate recipient cells proliferation, and promote tumor growth, metastasis, as well as the abnormal proliferation of normal human bronchial epithelial cells.