The clinical spectrum ranges from a severe, early-onset LAMA2-related congenital muscular dystrophy (LAMA2-CMD, OMIM 607,855) to a mild, childhood-onset autosomal recessive limb-girdle muscular dystrophy-23 (LGMDR23, OMIM 618,138) [2, 3]. The gene discussed is LAMA2; the disease is muscular dystrophy, limb-girdle, autosomal recessive 23.