The enzymes of glucose metabolism, including glucose transporter 1 (GLUT1), are regulated by HIF-1, and the expression of these genes regulated by HIF1 alters intracellular biological functions such as glucose uptake and energy production [7, 8], which is associated with cancer cell proliferation and poor prognosis in tumours [9, 10]. The gene discussed is SETD2; the disease is neoplasm.