TGFB1 and cancer: We observed an increased expression of genes involved in the following biological processes/signaling pathways in the high-risk subgroup, including ubiquitin mediated proteolysis (NES = 2.124, FDR < 0.001), Wnt signaling pathway (NES = 2.115, FDR < 0.001), mTOR signaling pathway (NES = 2.103, FDR < 0.001), TGF-β signaling pathway (NES = 2.059, FDR = 0.002), pathways in cancer (NES = 2.050, FDR = 0.002), MAPK signaling pathway (NES = 2.009, FDR = 0.04), RNA degradation (NES = 1.858, FDR = 0.013), and cell cycle (NES = 1.781, FDR = 0.021, Fig. 4A).