Based on the overexpression of growth factor receptors in both tumor types, we selected multi-tyrosine kinase inhibitors (TKI), comprising FGFR which were either approved for the treatment of advanced soft tissue sarcoma (pazopanib) or in clinical investigation (regorafenib, NCT02085148), and erlotinib for EGFR inhibition. Here, EGFR is linked to soft tissue sarcoma.