In contrast in FGFR1 overexpressing epithelioid sarcoma, regorafenib, as well as pazopanib, the latter being approved for the treatment of advanced soft tissue sarcomas since 2012, exhibited limited or no sensitivity, and activated the MAPK and PI3K/AKT/mTOR signaling pathways in both cell lines in vitro. This evidence concerns the gene FGFR1 and soft tissue sarcoma.