Thus, it may be of interest to do parallel studies with K14E5 transgenic mice in the context of our model of MmuPV1-mediated anal disease to determine if E5 contributes to increased persistence of MmuPV1 and/or increased anal carcinogenesis and whether cancers arising in the K14E5 mice retain MmuPV1. Here, ARHGEF15 is linked to anus disorder.