However, now, various approaches have been introduced to implement the reprogramming of tumor-associated macrophages, namely the signaling activation of toll-like receptors (TLR) and the stimulator of interferon genes (STING), using monoclonal antibodies, genetic and epigenetic intervention (i.e., the interference RNA application to silence the expression of immunosuppressive genes and activate the stimulatory pathways in macrophages), and also metabolic manipulation (i.e., the interference macrophage metabolic pathways) [39]. Here, STING1 is linked to neoplasm.