The db/db mouse is an animal model of obesity-related diabetes and can be used to study kidney changes due to diabetes [33] The db/db mouse is overweight, hyperglycemic and hyperinsulinemic and exhibits increased kidney weight, glomerular mesangial matrix and albumin excretion [34] The present study showed that ER-PA significantly reduced the body weight and food/water intake of db/db mice. Here, ALB is linked to obesity due to melanocortin 4 receptor deficiency.