IL33 and Alzheimer disease: A phase 2a proof-of-concept clinical trial of etokimab (ANB020), a humanized monoclonal antibody against IL-33, revealed a rapid response with EASI 50 of 83% and EASI 75 of 33% by day 29 with a single-dose injection in 12 adults with moderate to severe AD, and the response was sustained at day 57.