IGHE and Increased total eosinophil count: Apart from the localization of SM1 being linked to eosinophilia and IgE production loci, it also participates directly in regulating genes that encode for anti-inflammatory (IL-4, IL-5, IL-9 IL-13) and pro-inflammatory cytokines (IL-12 and IL-23), as well as CSF-IR, which is an interferon regulating factor-1 (IRF-1) that encodes IFN-inducible genes that include IFN-α and IFN-β [125,126].