Experiments conducted in IL-4/IL-4 receptor KO mice show that such an increase results in reduced hepatic granulomas and fibrosis, demonstrating that the IL-4 receptor is actually more central to the formation of granulomas [96] The IL-4-IL-13 receptor complex comprises three combinations, the more popular being the Type II receptor that consists of the IL-4Rα and IL-13Rα1, with both IL-4 and IL-13 employing the IL-4Rα chain [97]. The gene discussed is IL4R; the disease is Granuloma.