The granuloma cell population is in general a large aggregation of mononuclear phagocytes, plasma cells, neutrophiles, fibroblasts, and lymphocytes, but is typically composed of 50% eosinophilia, 30% macrophage, and 20% CD4+ T cells (Figure 3) [89,90]. This evidence concerns the gene CD4 and Increased total eosinophil count.