Therefore, miR-21 has been proposed as a novel target for the potential treatment of schistosome-induced hepatic fibrosis along with miR-454, whose expression has also been detected in the liver of schistosome-infected mice, which by targeting Smad4 is able to deactivate hepatic stellate cells and TGF-β1-induced LX-2 cells [77]. Here, TGFB1 is linked to Hepatic fibrosis.