INS and type 2 diabetes mellitus: Having in mind that skeletal muscle is an important organ for whole-body glucose homeostasis and that metabolic disturbances in the muscle could be one of the earliest defects leading to T2D, the aim of this study was to elucidate whether the combination of excessive fructose consumption and chronic unpredictable stress disturbs insulin signaling in the skeletal muscle of male rats through lipid-induced inflammation and changes in glucocorticoid signaling as a potential underlying mechanism for muscle insulin resistance.