Alpha lipoic acid (ALA), a drug sold in many countries over the counter and reported to reduce atherosclerosis and increase PGC-1α expression in mice, was postulated to increase TERT and ARE/ERE (antioxidant/electrophile-responsive element) signaling to decrease DNA damage and improve telomere functions [115,119,137]. The gene discussed is PPARGC1A; the disease is atherosclerosis.