Golestaneh et al. showed that PGC-1α along with SIRT1 (sirtuin 1) were repressed in RPE cells obtained by the dedifferentiation of induced pluripotent stem cells (iPSCs) obtained by reprogramming of skin fibroblasts of AMD and non-AMD donors [123]. This evidence concerns the gene PPARGC1A and age-related macular degeneration.