Senescence may be involved in AMD pathogenesis through several pathways, including oxidative stress response; DDR; humanin; degeneration of choriocapillaris mediated by membrane attack complex; the cyclic GMP-AMP synthase–stimulator of interferon genes (cGAS-STING) pathway; lipofuscin, including its fluorophore A2E (N-retinylidene-N-retinyl-ethanolamine), a byproduct of the visual cycle; and the amyloid-beta peptide (reviewed in [2]). Here, CGAS is linked to age-related macular degeneration.