LMNA and progeroid syndrome: Therefore, the search for new inhibitors of the interaction between progerin and lamin A with optimized pharmacokinetic properties continued until the identification of SLC-D011 or progerinin (Figure 5), a compound able to extend the life span of LmnaG609G/G609G progeroid mice after oral administration (50 mg/Kg, daily) and to improve histological and physiological hallmarks of progeria in Lmna+/G609G mice [51,61].