Nonetheless, L-B143 produced a significant extension of lifespan in the transgenic mouse model of HGPS that expresses the human LMNA gene with the classic G608G mutation when administered subcutaneously at doses of 17 mg/kg or 50 mg/kg, although some toxicity concerns were reported at the highest dose. Here, LMNA is linked to Hutchinson-Gilford progeria syndrome.