There was an enrichment of mutations in melanoma for a number of genes of the splicing machinery such as Small Nuclear Ribonucleoprotein Polypeptide E (SNRPE), SF3A3, and SF3B3. The SNRPE-encoded protein is a core component of U small nuclear ribonucleoproteins, which are key components of the pre-mRNA processing spliceosome. The gene discussed is SNRPE; the disease is melanoma.