Among the genes involved in these processes were MITF, BRAF, CDKN2A, YAP1, ARID1A, MC1R, and SOX10. In contrast, N2 nevi were enriched for signatures involved in endothelial- and stroma-specific genes, and M2-type melanomas were enriched for immune response signatures (AXL, KIT, EGFR, SMARCA2, PDCD1 (PD1), and CTLA4). This evidence concerns the gene CTLA4 and melanoma.