These activations temporally mimic the development of SS-like pathology within the salivary glands, with Rhoc, Cdc42, Rac3, and Rhou exhibiting early upregulation starting at 8 weeks of age, and with Rac2 and Rhobtb1 showing an upregulation at 16 weeks, an age when the adaptive response is observed in the salivary glands of these mice. Here, RHOU is linked to synovial sarcoma.