AR and pachyonychia congenita: Furthermore, Kampa et al. [75] suggested that flavanol dimers B1-B4 (oligomeric Pro) and in particular, oleylated B2 could be considered a therapeutic agent for advanced PC since it had a powerful agonist effect on membrane AR in androgen-independent DU145 PC cells (ProB2 > ProB3 = ProB4 > ProB1).