This study used mecp2 null mice as an experimental RTT model to investigate whether music exposure affects anxiety-like behavior and/or reciprocal social interactions and to probe whether the BDNF or TrKB signaling pathways in brain regions involving emotional control, including the prefrontal cortex, hippocampus, amygdala, and basal ganglia, are affected by a music-based intervention. This evidence concerns the gene NTRK2 and Anxiety.