Recent findings also identified that TLR9 and Beclin 1 crosstalk to regulate muscle function and glucose metabolism during exercise [78], and along with the NAD-dependent deacetylase SIRT3, act in synergy in mitochondria in response to empagliflozin, and may serve as a potential treatment strategy for HF [77]. The gene discussed is BECN1; the disease is hydrops fetalis.