In addition, other parameters of arterial stiffness, such as central pulse pressure, forward pressure wave amplitude, and backward (or reflected) pulse wave amplitude, also showed significant improvement after SGLT2 inhibitor use [62,63] Taken together, the reductions in central blood pressure, pulse pressure, and forward wave amplitude in patients with T2DM can improve endothelial function and vascular stiffness, which subsequently decreases cardiovascular events. Here, SLC5A2 is linked to type 2 diabetes mellitus.