NLRP3 and diabetic kidney disease: Uric acid is thought to increase oxidative stress and levels of reactive oxygen species, activate the renin–angiotensin–aldosterone system, increase levels of inflammatory cytokines, and induce activation of the NLRP3 (NACHT, LRR, and PYD domains-containing protein 3) inflammasome, seen in diabetic nephropathy and HF [51].