However, a retrospective study including 101 Brazilian p.R337H TP53 mutation-carrying family members with cancer, reported 11 cases of TC (10.9%), highlighting that, although TC is an uncommon manifestation of LFS in general, this malignancy appears to be a component of the spectrum of tumours in carriers with the TP53 p.R337H founder mutation [86]. The gene discussed is TP53; the disease is neoplasm.