TP53 and cancer: Finally, they concluded that new identified TP53 germline mutations, such as p.V73Wfs*50, are rare among patients with "sporadic" sarcoma but that they may be common in patients with sarcoma whose background includes either multiple primary cancers or a family history of cancer, thus identifying a group of patients with cancer who carry germline mutations of the TP53 gene more diverse than that suggested by the clinical definition of the LFS [98].