In ALL, the most frequently altered miRNAs are miR-181 cluster that is reported as upregulated by several studies and is considered a crucial oncomiR in childhood ALL [122]; miR-155, that induces pre-B cells clonal expansion and is overexpressed in different pediatric ALL subtypes [107]; miR-128b, that allows differentiation with AML cases and is downregulated in ALL with the MLL-AF4 translocation [105,121]. This evidence concerns the gene KMT2A and acute lymphoblastic leukemia.