DNMT3A and chronic myelogenous leukemia, BCR-ABL1 positive: Another example of epi-miRNA is miR-217, which was found to be downregulated in chronic myeloid leukemia (CML) K562 cells that were resistant to tyrosine kinase inhibitors (TKI); it was shown that by increasing miR-217 expression in these cells, a reduction of DNMT3A and a significantly increased efficacy of TKI were detected [39].