In CLL, known deregulated pathways are represented by circCBFB/miR-607/FZD3 inducing Wnt/b-catenin signaling, circMTO1/miR-337-3p/PML that is downregulated in CLL patients, and circ-RPL15/miR-146b-3p that inhibits the RAS/RAF1/MEK/ERK pathway [86,87,88]. The gene discussed is MAPK1; the disease is B-cell chronic lymphocytic leukemia.