Analysis of GSE60424 containing samples from ALS and healthy controls identified nine switch genes, including KDM6A, MAP7D2, ZFX, ERCC6L, IFI44L, XAF1, IFI44, EIF2S3, and XIST, using a fold change cut off of 1.5 (Figure 2). Here, XAF1 is linked to amyotrophic lateral sclerosis.