IL1B and COVID-19: Furthermore, there is also evidence suggesting the involvement of Nod-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation in the immuno-pathogenesis of severe COVID-19 by driving the cleavage of caspase-1 and secretion of IL1β and IL18 and other damage-associated molecular patterns (DAMPs) [18,19].