Moreover, our core analysis also identified three pathways, namely the role of MAPK signaling in inhibiting the pathogenesis of influenza (p < 3.86 × 10−32), coronavirus pathogenesis pathway (p < 1.79 × 10−30), and role of PKR in interferon induction and antiviral response (p < 4.98 × 10−30), all of which play key roles in antiviral response and pathogenesis following viral infections. Here, EIF2AK2 is linked to viral infectious disease.