CRP and Increased total leukocyte count: Laboratory investigations of the blood during an acute-phase situation show an elevated number of white cells [leukocytosis], mostly granulocytes; accelerated erythrosedimentation velocity; elevated serum levels of acute-phase proteins, such as C-reactive protein, serum amyloid A, fibrinogen, fibronectin v WF VIII, ceruloplasmin, alpha1 antitrypsin, lipocalin-2, lactoferrin, hepcidin, ferritin, and most of the complement proteins [9,10,11,12,13].