CYP2J2 and cancer: However, some of the previous studies in mice may not truly represent the physiological situation as they were performed by injecting cancer cells into animals overexpressing the human CYP2C8 or CYP2J2 enzymes in endothelial cells and a subset (Tie2-expressing) of myeloid cells, or following the systemic administration of high concentrations of 14,15-EET [7,13].