Many of the proteins expressed at significantly lower levels in tumors lacking the sEH were linked to metabolism and included pyrroline-5-carboxylate reductase 2, which is involved in proline synthesis and leads to cancer cell proliferation [34]; 6-pyruvoyl tetrahydrobiopterin synthase; and aspartate aminotransferase, the ratio of which, relative to alanine aminotransferase, generates the De Ritis ratio [35], that is associated with poorer prognosis in patients [36]. This evidence concerns the gene EPHX2 and cancer.