The grna ortholog gene is implicated in dementia, neurodegenerative disease, and neuronal ceroid lipofuscinosis 11; gsk3ba in Alzheimer’s disease, amyotrophic lateral sclerosis, bipolar disorder, and schizophrenia; fzd3a in Williams–Beuren syndrome and schizophrenia; zc4h2 in Miles–Carpenter syndrome, a neuronal retardation disease; neurod2 in early infantile epileptic encephalopathy; and nrsn1l in memory consolidation [42]. The gene discussed is ZC4H2; the disease is early-onset autosomal dominant Alzheimer disease.