IL1B and familial Mediterranean fever: Colchicine, a microtubule depolarizing drug with a potent anti-inflammatory activity, currently used to treat acute gout flares, familial Mediterranean fever (FMF), and acute pericarditis, disrupts the microtubule network and at the same time inhibits eATP-induced, P2X7R-dependent plasma membrane permeabilization to high MW dyes, ROS, nitric oxide (NO), and IL-1β release, without affecting ATP-evoked ion currents [67].