NLRP3 and atrophic macular degeneration: An investigation of an experimental model of AMD revealed that nucleoside reverse transcriptase inhibitors (NRTIs), such as stavudine and azidothymidine, are potent blockers of P2X7R and of the associated NLRP3 inflammasome activation, and accordingly, they prevent geographic atrophy and choroidal neovascularization [64].