IL6 and depressive disorder: This is because a protective effect of CRP on schizophrenia risk, as reported previously (Hartwig et al., 2017), fully attenuated in MVMR analysis after accounting for the effects of IL-6 and sIL-2Rα, and we didn’t find evidence for an association of CRP with depression, in line with other MR evidence (Kappelmann et al., 2021).