After taking into account CRP and sIL-2Rα, increased IL-6 levels were associated with increased risk for both schizophrenia (IVW OR=1.26; 95% C.I., 1.05-1.52) and major depression (IVW OR=1.08; 95% C.I., 1.03-1.12). The gene discussed is IL6; the disease is major depressive disorder.