This is because a protective effect of CRP on schizophrenia risk, as reported previously (Hartwig et al., 2017), fully attenuated in MVMR analysis after accounting for the effects of IL-6 and sIL-2Rα, and we didn’t find evidence for an association of CRP with depression, in line with other MR evidence (Kappelmann et al., 2021). This evidence concerns the gene IL6 and depressive symptom measurement.