From analyses of trans variants (Figure 1; Supplementary Tables 6-8), each SD increase in genetically-predicted levels of IL-9 (IVW OR=1.06; 95% C.I., 1.01-1.11) increased schizophrenia risk, while each SD increase in levels of CRP (IVW OR=0.92; 95% C.I., 0.85-0.99) and MCP-1 (IVW OR=0.96; 95% C.I., 0.91-0.99) decreased schizophrenia risk. The gene discussed is IL9; the disease is schizophrenia.