There was evidence of heterogeneity for trans variants of IL-1RA, sIL-2Rα, IL-4, IL-5, IL-13, CRP, BDNF, neutrophils and lymphocytes with schizophrenia (all p<0.05), but no evidence for major depression or bipolar disorder as outcomes (all p>0.05 (Supplementary Table 14). This evidence concerns the gene IL6R and schizophrenia.