ALOX5 and asthma: 13 5-Lipoxygenase-activating protein(FLAP) transfers arachidonic acid to 5-LOX at the nuclear membrane,where leukotriene (LT)A4 is synthesized via 5-hydro(pero)xyeicosatetraenoicacid (5-H(P)ETE) as an intermediate.14 LTA4 is converted to either the potent chemoattractant LTB4 or cysteinyl-LTs that elevate vascular permeability and triggersmooth-muscle contraction.15−17 LTs are central for asthma andallergic rhinitis and contribute to dermatitis, inflammatory liverdisorders, neurodegenerative diseases, cardiovascular disease, andcancer.14,15,18−21