Though no robust evidence is available in the management of such patients with CHIP and cardiovascular diseases, poorer outcomes seen in such patients with CAD, patients with heart failure, and patients with valvular heart diseases enunciate that an aggressive lifestyle modification including smoking cessation with control of risk factors like blood pressure, blood sugar, and cholesterol should be strongly considered as the first-line of therapy till we identify specific therapies that target CHIP mutations directly. This evidence concerns the gene STUB1 and heart failure.