Previous studies demonstrated that HDP was among the major causes of IUGR.40,42 In addition, preeclampsia was associated with ICP43,44,45 and IUGR.46 Various studies have supported that dysregulated placental angiogenic factors and antiangiogenic factors contribute to the development of preeclampsia and IUGR.47,48 In addition, the ratio of fms-like tyrosine kinase 1 to placental growth factor in maternal serum can project both preeclampsia and IUGR.49 Our unpublished data also found that excessive bile acid can disrupt the expression balance of these angiogenic factors in trophoblastic cells. This evidence concerns the gene FLT1 and fetal growth restriction.