TNF and atherosclerosis: For example, urolithin A, C, and D can reduce the accumulation of triglyceride, reducing the risk of animation atherosclerosis [39]; urolithiasis A and its sulfate conjugation may protect against breast cancer [40]; urolithin A has anti-inflammatory and antioxidant effects of [41]; urolithin A glucuronide and its aglycone urolithin A ameliorate TNF-alpha-induced inflammation [42], which made a great contribution to biological activity.