In a previous study, the same group identified, by phage display [45], cyclic tumor-homing peptide, LyP-1 (sequence: CGNKRTRGC, Figure 2c) containing a tumor-homing motif and a cryptic CendR motif (KRTR) able to be internalized by Neuropilin receptors (NRP), modular transmembrane proteins for various forms and isoforms of VEGF and members of the class 3 semaphorin family. Here, PTPN22 is linked to neoplasm.