Therefore, the aim of this investigation is to study the physico–chemical properties (microstructure; phase composition; roughness, thickness, and mass; electrostatic and zeta potentials) of CaP coatings on Ti plates prepared by MAO method at the different voltages of 200–300 V in relation to the in vitro examination of morphofunctional behavior of tumor Jurkat T cells preliminarily activated with anti-CD2/CD3/CD28 antibodiesand contacted with test CaP-coated samples. This evidence concerns the gene CD28 and neoplasm.