Recent single-nucleus transcriptomic profiling of mouse IRI-kidneys identified vascular cell adhesion molecule 1 (VCAM1) as a marker of non-repairing proximal tubular cell state (Kirita et al., 2020), and Vcam1 induction has been observed in multiple forms of human kidney diseases, including allograft rejection (Hauser et al., 1997). The gene discussed is VCAM1; the disease is kidney disorder.