Diabetic retinopathy and diabetic nephropathy are common microvascular alterations and zebrafish has been established as a valuable animal model to study alterations in the eyes and kidneys.[31, 32] The hyaloid vasculature was analyzed first by using the Tg(fli1: EGFP) reporter line.[33] Zebrafish larvae were collected at 5 dpf, and images were captured with a confocal microscope. This evidence concerns the gene FLI1 and diabetic retinopathy.