AKT1 and cancer: As the evidence of CTR1 in prediction of platinum‐based chemotherapeutics seems more controversial,[49, 50, 51] here we show that CTR1 plays an important role in positively regulating AKT kinase activity, which has been considered as one of the most important causes of cancer cell resistant to platinum‐based treatment.[52] More interestingly, in combination with copper chelator TTM, the efficiency of chemo‐drugs could be largely enhanced possibly due to the decrease of copper‐induced AKT activity and its oncogenic functions.