However, to further validate the tumor suppressor function of Nedd4l, the Nedd4l conditional knockout mice, particularly in lung tissues will be worth to generate and crossed with lung conditional KrasG12D mice,[48] to monitor the lung tumorigenesis, which would provide robust genetic evidence to elucidate whether Nedd4l plays critical roles in tumorigenesis by targeting CTR1‐AKT signaling pathway. This evidence concerns the gene NEDD4L and neoplasm.