EGFR and hypertensive disorder: As a result, the polymorphisms of NEDD4L are associated with human hypertension.[34, 35] Nedd4l has also been shown to negatively regulate several oncogenic proteins, such as EGFR, transforming growth factor beta (TGFβ) receptor and WNT signaling,[46, 47] however, the tumor suppressive roles of Nedd4l is not well defined yet.