AKT1 and neoplasm: In further support of the notion that the tumor suppressor function of Nedd4l is due to compromising AKT kinase activity, we found that depleting NEDD4L‐induced colony formation and anchorage‐independent growth could be largely abrogated in AKT1‐deficient MDA‐MB231 cells or AKT1/2 double knockout DLD1 cells (Figure 6k,l; Figure S7l–n, Supporting Information).