AKT1 and neoplasm: However, to further validate the tumor suppressor function of Nedd4l, the Nedd4l conditional knockout mice, particularly in lung tissues will be worth to generate and crossed with lung conditional KrasG12D mice,[48] to monitor the lung tumorigenesis, which would provide robust genetic evidence to elucidate whether Nedd4l plays critical roles in tumorigenesis by targeting CTR1‐AKT signaling pathway.