It is important to note that while hCG has potential to reverse hypogonadism and promote neurogenesis and cognitive recovery, an increase in circulating hCG/LH concentrations as a result of ovariectomy53, 54, 55, 56, 57, 58 or treatment59, 60 has been shown to impair cognition in rodents, while lowering LH or blocking LHCGR signalling is protective of memory in rodents53, 54, 56, 57, 58, 60, 61, 62, 63 and humans.35 The gene discussed is PLOD1; the disease is hypogonadism.