KDM1A and carcinoma: Likewise, thoughtful discussions on the regulation of epithelial-mesenchymal transition (EMT) programs and carcinoma plasticity also extend into new arenas of: (1) epigenetic modification of histones by lysine-specific demethylase (LSD1 or KDM1A[15]); (2) spatiotemporal control of the translatome coupled to EMT by aberrant expression and activation of hnRNP E1[16]; and (3) mRNA splicing factors and their essential contribution to the acquisition of EMT and metastatic phenotypes[17].