Hyperglycemia is a sign of impaired insulin sensitivity, and previous studies have found ES to either have no effect, increase or decrease (various measures of) insulin sensitivity, partly depending on diet and sex of the animal, with males potentially being more vulnerable to develop insulin insensitivity (Jaimes-Hoy et al., 2019b; Maniam and Morris, 2010; Mela et al., 2012; Murphy et al., 2017). Here, INS is linked to Hyperglycemia.