Accordingly, this meta-analysis revealed that SGLT2 inhibitors vs. placebo significantly reduced HHF and KSCO and increased KCCQ total score in patients without T2DM and did not significantly affect CVD and ACM, while SGLT2 inhibitors lowered the risks of serious adverse event and kidney adverse event in this vulnerable population and did not lead to the increased risks of volume depletion, fracture, amputation, major hypoglycemia, and diabetic ketoacidosis. Here, SLC5A2 is linked to type 2 diabetes mellitus.