Based on KEGG pathway enrichment analysis, 9 pathways were enriched (with a threshold of p < 0.05) among the upregulated integrated DEGs; these pathways included cytokine-cytokine receptor interaction, rheumatoid arthritis, the interleukin-17 (IL-17) signaling pathway, the hypoxia-inducible factor (HIF)-1 signaling pathway and the tumor necrosis factor (TNF) signaling pathway; 8 pathways were enriched among the downregulated integrated DEGs; these pathways included the wnt signaling pathway, PPAR signaling pathway, and heart process-related pathways. The gene discussed is TNF; the disease is rheumatoid arthritis.