Ho et al. investigated the role of HOMX-1 in angiotensin II-induced AAA formation in HO-1+/+apoE-/- and HO-1-/-apoE-/- mice and demonstrated the essential roles of HOMX-1 in suppressing the pathogenesis of abdominal aortic aneurysm (61). This evidence concerns the gene HMOX1 and abdominal aortic aneurysm.