By contrast, oxygen-carrying tactics are realized by physical dissolution or chemical conjugation in oxygen carriers including perfluorocarbons (PFCs) (Krafft, 2020), hemoglobin (Hb) (Yang J. et al., 2018) and metal-organic framework (MOF) (Xie et al., 2018) to directly release oxygen in tumor hypoxic regions. This evidence concerns the gene GSTM1 and neoplasm.