CAT and neoplasm: Compared with traditional drug delivery strategy, the NC drug delivery system is considered to be a promising tool to load anti-tumor drugs and oxygen carriers or generators for tumor therapy owing to their several advantages: 1) increasing half-life of vulnerable drugs and proteins such as CAT; 2) improving the solubility of unstable drugs; 3) allowing surface modified to realize tumor targeting; and 4) achieving sustained and controlled release of drugs in tumors.