ALB and neoplasm: In 2016, there was two publications that utilized HA modification (Song M. et al., 2016; Gao et al., 2017), one paper used HSA coating (Chen et al., 2016), and one report employed PEGylation (Zhu et al., 2016) to construct intravenous MnO2-based NCs for tumor oxygenation, respectively.